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643 Grand Avenue, South San Francisco CA 94080
643 Grand Avenue, South San Francisco CA 94080
California>South San Francisco>Downtown South San Francisco

643 Grand AvenueSouth San Francisco, CA 94080

For Sale

$998,888

Smart Buyer Rebate $9,989

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging and an additional 2 car off street parking in front of the house. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Listed by Jill Penna

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License #01895080

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Christie's International Real Estate Sereno

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4152448630

Last updated October 07, 2026

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Source: CRMLS #ML82059314

Listing Facts

  • TypeSingle-family
  • NeighborhoodDowntown South San Francisco
  • Bedrooms3
  • Bathrooms4
  • Days on Prevu65
  • Size1,630 sqft
  • Price per sqft$613

Amenities

  • Dishwasher
  • Parking

Location

Mortgage Calculator

Listing History

09/30/2026
Price Decreased
$998,888
08/27/2026
Listed by Christie's International Real Estate Sereno
$1,248,000
  1. 09/30/2026$998,888
    Price Decreased
  2. 08/27/2026$1,248,000
    Listed by Christie's International Real Estate Sereno

Property Details for 643 Grand Avenue

Exterior

Construction

  • Roof: Shingle
  • Stories Total: 2
  • Window Features: Skylight(s)
  • Year Built: 1895
  • Common Walls: No Common Walls

Measurements

  • Lot Size Acres: 0.08
  • Lot Size Area: 3,500
  • Lot Size Source: Assessor
  • Lot Size Square Feet: 3,500
  • Lot Size Units: Square Feet

Financial

Taxes

  • Parcel Number: 012241120

Interior

Features

  • Appliances: Dishwasher, Disposal, Refrigerator
  • Flooring: Wood

Measurements

  • Living Area: 1,630
  • Living Area Source: Assessor

Rooms

  • Bathrooms Full: 4
  • Bathrooms Total Integer: 4
  • Bedrooms Total: 3

Parking

Parking

  • Garage Spaces: 2
  • Garage: Yes
  • Parking Total: 2

Schools

High School

  • High School District: South San Francisco Unified

Utilities

Equipment

  • Has Cooling: Yes
  • Heating: Central
  • Has Heating: Yes
  • Sewer: Public Sewer
  • Water Source: Public

Frequently Asked Questions

How many bedrooms and bathrooms does this single-family home have?

There are 3 bedrooms and 4 bathrooms in this single-family home at 643 Grand Avenue.

Does this single-family home have parking?

Yes, there are 2 parking spaces available for 643 Grand Avenue.

How does 643 Grand Avenue compare to other single-family homes in Downtown South San Francisco?

This single-family home is listed 35% below the average price for single-family homes in Downtown South San Francisco and has been on the market for 70 less days than the typical home in this area.

What is the square footage on this single-family home?

According to the MLS, this listing is 1,630 sqft.

643 Grand Avenue is a 3-bedroom, 4-bath single-family home for sale in South San Francisco CA 94080. Available on Prevu for 65 days at $998,888. This includes a recent price decrease of $249,112. This home features 1,630 square feet of living space, located in Downtown South San Francisco. The median listing price for single-family homes in this area is $1,058,500. Additional amenities include dishwasher and parking. Browse more single-family home listings in South San Francisco.

Based on information from California Regional Multiple Listing Service, Inc. and/or other sources. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by Prevu or the MLS. Information is provided exclusively for consumer's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumer may be interested in purchasing.

Full MLS Disclaimers

Rebate estimate is indicative only and based on listing price and estimated buyer's agent commission paid by owner, if applicable. Final rebates are subject to Terms of Use and may vary due to final negotiated transaction terms.