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643 Grand AvenueSouth San Francisco, CA 94080

For Sale

$1,248,000

Smart Buyer Rebate $12,480

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Listed by Jill Penna

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License #01895080

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Christie's International Real Estate Sereno

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415-244-8630

Last updated September 10, 2026

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Source: MLSListings #ML82059314

Listing Facts

  • TypeSingle-family
  • NeighborhoodDowntown South San Francisco
  • Bedrooms3
  • Days on Prevu20
  • Size1,630 sqft
  • Price per sqft$766

Amenities

  • Pets Allowed
  • Parking

Location

Mortgage Calculator

Listing History

08/27/2026
Listed by Christie's International Real Estate Sereno
$1,248,000
  1. 08/27/2026$1,248,000
    Listed by Christie's International Real Estate Sereno

Property Details for 643 Grand Avenue

Exterior

Construction

  • Roof: Shingle
  • Stories: 2
  • Year Built: 1895
  • Year Built Details: 2

Measurements

  • Building Area Total: 1,630
  • Lot Size Area: 3,500
  • Lot Size Source: Assessor
  • Lot Size Square Feet: 3,500
  • Lot Size Units: Square Feet

Financial

Taxes

  • Parcel Number: 012-241-120

Interior

Features

  • Appliances: Water Softener
  • Interior Features: Skylight(s), Walk-in Closet

Measurements

  • Living Area: 1,630

Rooms

  • Bathrooms Full: 4
  • Bedrooms Total: 3

Parking

Parking

  • Garage Spaces: 2
  • Garage: Yes
  • Parking Features: Detached, On Street

Schools

Elementary School

  • Elementary School District: South San Francisco Unified

High School

  • High School District: South San Francisco Unified

Utilities

Equipment

  • Heating: Central Forced Air
  • Sewer: Public Sewer
  • Utilities: Public Utilities, Water - Public
  • Water Source: Public

Frequently Asked Questions

How many bedrooms does this single-family home have?

There are 3 bedrooms in this single-family home at 643 Grand Avenue.

Does this single-family home have parking?

Yes, there are 2 parking spaces available for 643 Grand Avenue.

How does 643 Grand Avenue compare to other single-family homes in Downtown South San Francisco?

This single-family home is listed 33% below the average price for single-family homes in Downtown South San Francisco and has been on the market for 49 less days than the typical home in this area.

What is the square footage on this single-family home?

According to the MLS, this listing is 1,630 sqft.

643 Grand Avenue is a 3-bedroom single-family home for sale in South San Francisco CA 94080. Available on Prevu for 20 days at $1,248,000. This home features 1,630 square feet of living space, located in Downtown South San Francisco. The median listing price for single-family homes in this area is $1,249,000. The home offers pets allowed and parking. Browse more single-family home listings in South San Francisco.

The data relating to real estate for sale on this display comes in part from the Internet Data Exchange program of the MLSListings™️ MLS system. Real estate listings held by brokerage firms other than Prevu Real Estate are marked with the Internet Data Exchange and detailed information about them includes the names of the listing brokers and listing agents. Based on information from the MLSListings MLS) as of 09/10/2026. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information. Data Services by Constellation Data Labs. IDX display powered by Prevu Real Estate. Copyright 2026 MLSListings Inc. All rights reserved.

Full MLS Disclaimers

Rebate estimate is indicative only and based on listing price and estimated buyer's agent commission paid by owner, if applicable. Final rebates are subject to Terms of Use and may vary due to final negotiated transaction terms.